Lipid profiling of polarized human monocyte-derived macrophages
نویسندگان
چکیده
منابع مشابه
Dysregulation of lipid metabolism in Tangier monocyte-derived macrophages.
The cellular defect in Tangier mononuclear phagocytes (MNP) was shown to be associated with significant abnormalities in cellular phospholipid, triglyceride, and cholesteryl ester metabolism by using various radiolabeled precursors (32Pi, 3H-serine, 3H-choline, 14C-acetate, and 14C-oleic acid). Tangier MNP expressed increased rates of synthesis for phospholipids (twofold), triglycerides (fivefo...
متن کاملMetabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages.
We evaluated cellular metabolism profiles of HIV-1 and HIV-2 infected primary human monocyte-derived macrophages (MDMs). First, HIV-2 GL-AN displays faster production kinetics and greater amounts of virus as compared to HIV-1s: YU-2, 89.6 and JR-CSF. Second, quantitative LC-MS/MS metabolomics analysis demonstrates very similar metabolic profiles in glycolysis and TCA cycle metabolic intermediat...
متن کاملPopulation of Monocyte-Derived Macrophages
Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner, Kile Green, Rachel Dickinson, Xiao-nong Wang, Donovan Low, Katie Best, Samuel Covins, Paul Milne, Sarah Pagan, Khadija Aljefri, Martin Windebank, Diego Miranda-Saavedra, Anis Larbi, Pavandip Singh Wasan, Duan Kaibo, Michael Poidinger, Venetia Bigley, Florent Ginhoux, Matthew Collin,* and Muzlifah Han...
متن کاملQuantification and comparison of TLR2 activity in monocyte-derived macrophages of zebu and crossbred cattle
The present study was conducted to quantify and compare TLR2 (toll-like receptor 2) activity in monocyte-derived macrophages of zebu (Tharparkar) and crossbred (Holstein-Friesian × Jersey × Brown Swiss × Hariana) cattle. The cells were either induced with Pam3CSK4 or kept as control. The TLR2 activity was quantified in terms of IκB-α inhibitory subunit (NFKBIA) messenger RNA (mRNA) copies...
متن کاملEstrogen and progesterone reduce lipid accumulation in human monocyte-derived macrophages: a sex-specific effect.
BACKGROUND Males have an earlier onset and greater prevalence of clinical atherosclerosis than age-matched females, which is consistent with an atheroprotective effect of the female sex steroids, estrogen and progesterone. We therefore examined the effects of estrogen and progesterone on human foam cell formation, a key early event in atherogenesis. METHODS AND RESULTS Monocytes from healthy ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Prostaglandins & Other Lipid Mediators
سال: 2016
ISSN: 1098-8823
DOI: 10.1016/j.prostaglandins.2016.11.002